The San Francisco 49ers are no strangers to success, but the legendary team has a greater chance this season than in prior years.
With a win over the New York Giants on Thursday night, the 49ers will have only their second 3-0 start in 25 years, with the other coming in 2019. Stopping San Francisco might prove difficult for New York, which will be without Saquon Barkley as he recovers from an ankle injury. The Giants, on the other hand, came back from a 21-point deficit to overcome the Arizona Cardinals last Sunday for their first win of the season.
Check back for a live analysis of the game on USA TODAY Sports:
49ers 17, Giants 12: Matt Breida puts New York into the end zone for the first time.
Matt Breida exacted some vengeance on his old teammates.
✅ First NFL catch
✅ First NFL TDThe 7th-round pick Ronnie Bell gives the @49ers the lead 🙌 @Ronnieb_8#NYGvsSF on Prime Video
Also available on #NFLPlus https://t.co/qDMTitTfP0 pic.twitter.com/Ts2t7TluPV— NFL (@NFL) September 22, 2023
On his way to an eight-yard score, the Giants running back got a handoff from Daniel Jones, surged up the middle, and broke a couple arm tackles.
Breida’s touchdown was New York’s first of the game, bringing the score to 17-12 after the Giants failed to complete a two-point conversion.
On the night, Breida has four runs for 17 yards and one touchdown. From 2017 to 2019, the 28-year-old running back was a member of the San Francisco 49ers. Tyler Dragon’s
Christian McCaffrey has equaled Jerry Rice’s touchdown streak.
Christian McCaffrey is not alone.
McCaffrey’s four-yard touchdown run in the second quarter recorded his 12th touchdown run in a row (regular season or postseason). This ties the franchise record set in 1987 by receiver Jerry Rice.
The NFL record for the most consecutive games with a touchdown is 18. Hall of Fame running back LaDainian Tomlinson scored a touchdown in 18 consecutive games while playing for the San Diego Chargers in 2004 and 2005, tying the NFL record set by Baltimore Colts halfback Lenny Moore in 1965. — Cynthia Henderson
Trent Williams hits A’Shawn Robinson late in the game.
The start of halftime was delayed due to a violent fight between 49ers left tackle Trent Williams and Giants defensive lineman A’Shawn Robinson, as referee Shawn Hochuli instructed both teams to remain on the field as they attempted to move for the tunnels.
Matt Breida just made it a one-possession game 👀 @MattBreida#NYGvsSF on Prime Video
Also available on #NFLPlus https://t.co/qDMTitSHZs pic.twitter.com/5QT2OR4KOG— NFL (@NFL) September 22, 2023
It was the 49ers’ final play of the half, a kneel-down. Robinson ended up in Williams’ face, which irritated the guardian of Purdy’s blind side. Williams delivered a right hook to Robinson when they were temporarily entangled. Both players were penalized for unsportsmanlike behavior. In the game, Williams has been penalized three times. — Christopher Bumbaca
Graham Gano hits a 56-yard field goal to give the 49ers a 17-6 victory over the Giants.
Late in the first half, Darren Waller and the Giants offense showed flashes of life.
Waller grabbed two receptions in New York’s eight-play drive, which helped the team get into field goal range. Gano hit a long 56-yard field goal after the Giants failed to convert a third down to trim the Giants’ deficit to 17-6. Tyler Dragon’s
Christian McCaffrey boosts the 49ers’ lead at 17-3 over the Giants.
Even when Brock Purdy misses a throw, the ball ends up in the hands of 49ers receivers.
Purdy misfired on a slant route with Deebo Samuel, and the ball was deflected high in the air. Rookie wide receiver Ronnie Bell, on the other hand, moved beneath the ball and made the difficult grab for the first down.
Both 49ers running backs are off to strong starts. McCaffrey capped off the drive with a running touchdown, his 12th in a row, and now has 61 yards on the ground. He has three catches for 26 yards as well. On the drive, Elijah Mitchell had a nine-yard reception and an 18-yard run. Tight end George Kittle seemed to be stopped short of the first down on third-and-12 from the red zone. However, a roughing the passer flag on Leonard Williams – he fell with his entire body weight on Purdy, according to referee Shawn Hochuli – prolonged the drive and allowed the Niners to expand their advantage to 14 points at halftime. — Christopher Bumbaca

So far, Darren Waller has a blank.
Darren Waller was anticipated to play a significant role in the Giants’ gameplan on Thursday night, especially given the absence of running back Saquon Barkley (ankle). Late in the second quarter, though, the Giants’ tight end had zero receptions and no targets. Daniel Jones has thrown to six different players this season, none of whom have been Waller.
Waller has nine catches for 112 yards in two games before to Thursday night. Tyler Dragon’s
Mr. Irrelevant to 2023 seventh-round selection scoring strike, 49ers 10, Giants 3.
The Niners converted three third-down opportunities and were rewarded with a touchdown to make the score 10-3.
On third-and-15, head coach Kyle Shanahan called for a wide-receiver screen to Deebo Samuel, who gained 30 yards. On the play, guard Aaron Banks managed to block two Giants defenders, and Samuel took advantage of his block to unleash him for the huge gain.
McCaffrey then took over behind the offensive line, rushing for nine and ten yards. Shanahan called another screen, this time to McCaffrey, who sneaked away for 17 yards on 3rd-and-13. Purdy lofted a pass in the front corner of the end zone for wideout Ronnie Bell from the Giants’ 11-yard line on third down. Purdy, the final choice in the 2022 draft, came down with it and grabbed his first career touchdown (he got his first professional catch earlier in the game).
So far, San Francisco has converted six of eight third-down opportunities. — Christopher Bumbaca
The Giants and the 49ers were deadlocked at the end of the first quarter.

Nick Bosa, the reigning NFL Defensive Player of the Year, nearly had a safety late in the first quarter. Bosa broke free from the line of scrimmage and sacked Giants QB Daniel Jones near the goal line. Jones was given forward progress and the ball was placed within the one-yard line by the umpires. As the first quarter came to a close, the Giants faced a second-and-18 situation. Tyler Dragon’s
49ers 3, Giants 3: New York responds with their own field goal.
The Giants responded to San Francisco’s first drive field goal with their own.
Graham Gano, who kicked the game-winning field goal against the Arizona Cardinals four days ago, connected on a 44-yard from goal to tie the game at 3. New York has scored on six consecutive possessions dating back to the start of the second half of that game.
Quarterback Daniel Jones completed four passes to four different receivers for a total of 38 yards. He also converted a third-and-1 by getting just enough yardage on a sneak. — Christopher Bumbaca
49ers 3, Giants 0: The 49ers settle for a field goal on their first possession.
The 49ers took control of the ball to start the game. Running back Christian McCaffrey gained 29 yards from scrimmage and wide receiver Jauan Jennings caught a 24-yard pass on third down to put the team in field goal range.
Kicker Jake Moody scored the game’s opening points with a 28-yard field goal. Tyler Dragon’s
What time does the Giants-49ers game on ‘Thursday Night Football’ begin?
On Sept. 21, the Giants and 49ers will face off at 8:15 p.m. ET.
How do I watch the Giants versus. 49ers game on ‘Thursday Night Football’?
The Giants versus. 49ers game will be available on Amazon Prime Video and will only be shown in local markets. Fubo also offers free streaming of the game.
Inactives for the Giants and 49ers on Thursday night: Brandon Aiyuk is no longer with us.
The 49ers will be without starting wide receiver Brandon Aiyuk, who suffered a shoulder injury in Week 2 against the Los Angeles Rams. In addition, the 49ers confirmed that QB Brandon Allen, OL Nick Zakelj, RB Tyrion Davis-Price, LB Jalen Graham, DL Kalia Davis, and CB Ambry Thomas will be inactive against the Giants.
The Giants will be without starting running back Saquon Barkley due to an ankle injury suffered in last week’s triumph over the Arizona Cardinals. Inactive for the Giants on Thursday night are CB Cor’Dale Flott, S Gervarrius Owens, OLB Azeez Ojulari, OL Ben Bredeson, T Andrew Thomas, and DL Jordon Riley.
Odds for Giants vs. 49ers
According to BetMGM, the 49ers are 10.5-point favorites on Thursday.
NFL Week 3 props include moneylines, point spreads, and over/under totals.
Giants versus. 49ers predictions
All eight of USA TODAY Sports’ NFL experts are rolling with the 49ers, with five of them selecting the game as the lock of the week.
Here’s more on what they expect:
Lorenzo Reyes: 49ers 27, Giants 13
Short week and a West Coast trip, New York’s offensive line is a mess and the Giants will be without Saquon Barkley. The Niners are explosive pretty much everywhere. Nick Bosa is going to have a field day.
Tyler Dragon: 49ers 28, Giants 10
The 49ers are the best team in the NFL after two weeks. Brock Purdy is managing the game and getting the football to San Francisco’s explosive playmakers. The 49ers’ defense is once again stout with linebacker Fred Warner and defensive end Nick Bosa leading the way. The Giants will be without Saquon Barkley (ankle), which means it’s going to be a long night for New York.
Victoria Hernandez: 49ers 32, Giants 13
The Giants have good momentum after scoring all 31 points in the second half during their come-from-behind win last week but will struggle again without Saquon Barkley. The 49ers are simply the better team all around.
Jordan Mendoza: 49ers 30, Giants 12
The Giants were able to pull off a miraculous comeback in Week 2, but that was against the lowly Arizona Cardinals. Falling behind the 49ers is not something they’ll be able to overcome – especially without Saquon Barkley – as San Francisco cruises to an easy win.
Betting odds: 49ers among best bets for NFL Week 3
Highlighting Thursday Night Football odds, the San Francisco 49ers are among the best bets for NFL Week 3 in their primetime game against the visiting New York Giants. The undefeated 49ers are favored by 10 points, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.
According to the top NFL betting apps, 49ers quarterback Brock Purdy has some of the best NFL MVP betting odds (+2000) in his second professional season. The 49ers also boast some of the best early Super Bowl betting odds (+600).
The Giants, meanwhile, are not among the most popular NFL future bets after starting 0-2 on the heels of making the playoffs last season. Can Daniel Jones and Co. turn things around in 2023?
Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Sunday Night Football odds, Monday Night Football odds and more.
If you’re new to sports betting, don’t worry. We have tips for beginners on how to place bet online. And USA TODAY readers can claim exclusive promos and bonus codes with the online sportsbooks and sports betting sites. — Richard Morin
NFL Week 3 picks
Week 3 of the 2023 NFL season dawns with nine undefeated teams and nine winless ones. Our panel of NFL experts is back with a fresh round of prognostications.
Which 2-0 teams are legitimate playoff contenders?
Entering Week 3, there are nine 2-0 teams. Seven of those teams are from the NFC, including the San Francisco 49ers. Michael Middlehurst-Schwartz attempted to sort through all of the 2-0 teams to determine which are contenders, which are still in wait-and-see mode and which are fool’s gold.
Ranking 0-2 teams by playoff viability: Who still has hope?
Week 3 fantasy football rankings
Another week, another running back out for the season. And that’s on top of the various bumps and bruises those primary ballcarriers have to withstand on any given NFL weekend. As a result, the position is looking extremely thin as we head into Week 3.
This week’s fantasy football rankings are based on the point-per-reception (PPR) scoring used in most seasonal and daily fantasy football formats. One point is awarded for every 10 rushing and receiving yards and one point for every 20 passing yards. Six points are awarded for touchdowns scored, four points for passing TDs and one point for receptions.
Rankings are compiled by Daniel Dobish