Jimmie Kaylor, a seasoned NFL, college football, and DFS expert for SportsLine, has unveiled his predictions, picks, and top bets for the Oregon vs. Colorado game—a pivotal faceoff marking the Pac-12 conference debut for coach Deion Sanders and QB Shedeur Sanders.
Head coach Deion Sanders guides the No. 19 Colorado Buffaloes (3-0) into what promises to be a challenging match as they visit Autzen Stadium in Eugene, Ore., to battle the No. 10 Oregon Ducks (3-0) in the Pac-12 Conference opener for both squads. The Buffs are riding high after a thrilling 43-35 double overtime victory against in-state rival Colorado State. Shedeur Sanders, a Heisman Trophy hopeful, showcased his mettle with a stellar performance, racking up 348 yards, four touchdowns, and one interception. On the other side, the Ducks are fresh from a dominating 55-10 victory over Hawaii, featuring Bo Nix’s three touchdown passes. However, CU will miss two-way standout Travis Hunter due to an injury sustained against Colorado State.

The kickoff is set for 3:30 p.m. ET at Autzen Stadium. The consensus odds for Colorado vs. Oregon indicate the Ducks as 21-point favorites, with the over/under set at 70. Before placing any bets or making picks for Oregon vs. Colorado, ensure to delve into the astute college football predictions and betting guidance from SportsLine’s football expert, Jimmie Kaylor.
Kaylor brings a wealth of experience, having covered the NFL and college football for almost a decade as a Pro Football Writers of America member. With a background as a former college football All-American and NFL player, he possesses a unique perspective when devising fantasy lineups and locking in betting choices. Hailing from Colorado, Kaylor has a pulse on both the local and national sports scenes and has enjoyed substantial winnings from Denver area teams over the last two years.

Kaylor’s predictions for Colorado this season have been on fire, boasting a 4-1 record on his best bets during the Buffs’ initial three games of the season. Anyone following his picks has seen substantial gains.
Now, Kaylor shifts his focus to the Colorado vs. Oregon matchup, having precisely determined his picks and CFB predictions. Head to SportsLine to check out Kaylor’s picks. Several college football odds and betting lines for Oregon vs. Colorado are as follows:
- Colorado vs. Oregon spread: Oregon -21
- Colorado vs. Oregon over/under: 70 points
- Colorado vs. Oregon money line: Oregon -964, Colorado +602
- CU: QB Shedeur Sanders averages 417 passing yards per game
- ORE: The Ducks boast a 7-1 record at Autzen Stadium under head coach Dan Lanning and QB Bo Nix
A stampede is comin’ 🦬 pic.twitter.com/lgepFOwRWz
— Colorado Buffaloes Football (@CUBuffsFootball) September 23, 2023
Colorado possesses a potent offense, spearheaded by junior quarterback Shedeur Sanders, a Heisman Trophy contender with exceptional stats in his debut season at Colorado. Sanders has showcased impressive accuracy, completing 78.7% of his passes for 1,251 yards, 10 touchdowns, and just one interception. Sanders’ leadership was evident during a game-defining 98-yard drive against Colorado State.
Sanders’ primary targets, Xavier Weaver and Jimmy Horn Jr., have also excelled this season, adding to Colorado’s offensive prowess. Weaver, a transfer from South Florida, has made a significant impact with 25 receptions for 386 yards and two touchdowns, while Horn, another transfer from South Florida, has 26 receptions for 242 yards and two TDs. Their speed and elusiveness pose a significant threat to Oregon’s defense.
On the other side, the Ducks boast their own Heisman Trophy contender, fifth-year senior Bo Nix, who has demonstrated exceptional performance during his tenure at Oregon. In three games, Nix has completed 77.6% of his passes for 893 yards and eight touchdowns, impressively avoiding any interceptions this season. Nix benefits from playing behind one of the Pac-12’s strongest offensive lines, having been sacked only once in three games. Wide receiver Troy Franklin has also been pivotal for Oregon, amassing 17 catches for 292 yards and three touchdowns this season.
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Kaylor has extensively analyzed this matchup and is leaning towards an Over bet on the point total. Additionally, he’s identified a critical X-factor that guides his choice of the spread. To unveil his insights and determine which side to back, head to SportsLine.
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